Testing for PBT and vPvB properties


PBT and vPvB refer to substances with "Persistent, Bioaccumulative and Toxic" or "very Persistent and very Bioaccumulative" properties.

The assessment of PBT and vPvB properties is part of the chemical safety assessment required under the REACH Regulation. The chemical safety assessment shall be conducted for substances that are subjects to registration and manufactured or imported into EU in quantities of 10 tonnes or more per year, and for substances that are subjects to authorization.

ISO and GLP compliance
DHI performs ecotoxicological tests and QSARs aiming at the screening as well as the definitive criteria for P, vP, B, vB and T (see list below). At our ecotoxicological laboratory we perform tests in accordance with ISO 17025, accredited by DANAK (the Danish Accreditation and Metrology Fund) and in compliance with the OECD Principles of Good Laboratory Practice (GLP).

Persistence (P and vP)

Test description

Guideline

Ready biodegradability

OECD 301

Enhanced ready biodegradability

Modified OECD 301

Inherent biodegradability

Zahn-Wellens OECD 302B
MITI II test OECD 302C

Biowin 2/ 3/ 6 (QSAR)

EPI suite (US-EPA)

Aerobic and anaerobic transformation in soil

OECD 307

Aerobic and anaerobic transformation in aquatic sediment systems

OECD 308

Simulation test – aerobic mineralization in surface water

OECD 309

Bioaccumulation (B and vB)

Test description

Guideline

Log Pow (QSAR)

EPI suite (US-EPA)

Log Pow

OECD 117

Bioaccumulation in fish

OECD 305

Toxicity (T)

Test description

Guideline

Short-term aquatic toxicity

OECD 201, 202, 203

Long-term, chronic aquatic toxicity

OECD 210, 211

Want to know more ?

DHI Laboratory

lab-dk@dhigroup.com